It's about 0.0000003 times as long as The First spaceflight (Sputnik)
In other words, 2.250 seconds is 0.000000280 times the length of The First spaceflight (Sputnik), and the length of The First spaceflight (Sputnik) is 3,600,000 times that amount.(a.k.a. Sputnik 1, a.k.a. Спутник-1, a.k.a. "Satellite-1", a.k.a. Простейший Спутник-1) (1957) (total time in orbit)
Launched from Kazakhstan in 1957, Sputnik was the first artificial satellite placed into orbit around Earth, where it remained for 7,900,000 seconds. During its voyage, it traveled about 70,000,000 km (43,495,983.46 mi), completing an orbit of the planet every 5,800 seconds.
It's about 0.0000004 times as long as The Voyage of the Mayflower
In other words, 2.250 seconds is 0.000000390 times the length of The Voyage of the Mayflower, and the length of The Voyage of the Mayflower is 2,600,000 times that amount.(1620)
Having left Southampton, England on September 16th (new style), 1620, the Mayflower dropped anchor near Cape Cod, Massachusetts 5,700,000 seconds later on November 21st (new style), 1620. The voyagers had planned to travel in a convoy of two ships, but the smaller Speedwell was found to be leaking (evidently as a result of sabotage) and all passengers had to be moved to the Mayflower instead.
It's about 0.0000004 times as long as Columbus' voyage to America
In other words, 2.250 seconds is 0.000000400 times the length of Columbus' voyage to America, and the length of Columbus' voyage to America is 3,000,000 times that amount.(1492) (first voyage)
Attempting to find a western route to Asia, Christopher Columbus set sail on August 3rd, 1492 and landed in the Bahamas on October 12th — 6,000,000 seconds later. After one of Columbus' ships, the Santa Maria ran aground in present-day Haiti, he ordered that the timber be used to used to build a fort and settlement called La Navidad; it remains missing to archaeologists to this day.
It's about 0.0000005 times as long as The First US Continental Congress
In other words, 2.250 seconds is 0.000000510 times the length of The First US Continental Congress, and the length of The First US Continental Congress is 2,000,000 times that amount.(1774) (Philadelphia, Pennsylvania)
The First Continental Congress — which included such notable members as Samuel Adams, Thomas Paine, Patrick Henry, John Jay and George Washington — met from September 5th to October 26th, 1774 — a total of 4,400,000 seconds. Of the thirteen original American colonies in existence at the time, only the Province of Georgia sent no delegates to the Congress.
It's about 0.0000009 times as long as a William Henry Harrison's Presidency
In other words, 2.250 seconds is 0.00000082630 times the length of a William Henry Harrison's Presidency, and the length of a William Henry Harrison's Presidency is 1,210,000 times that amount.(a.k.a. William Henry Harrison, a.k.a. "Tippecanoe," a.k.a. "Old Tippecanoe") (1841)
Having caught pneumonia and pleurisy early in his term as President of the United States, William Henry Harrison died after 2,723,000 seconds minutes in office. Following his death, Congress approved a Presidential widow's pension for Harrison's wife, Anna Symmes, who received a year's worth of Harrison's presidential salary — $25,000 — and the right to free postage for the remainder of her life.
It's about one-six-hundred-thousandth as long as Boniface VI's reign
In other words, 2.250 seconds is 0.00000170 times the length of Boniface VI's reign, and the length of Boniface VI's reign is 590,000 times that amount.(AD 896)
The Church's enigmatic, shortest-reigning Pope, Boniface VI was pontiff for a period of 1,300,000 seconds in AD 896 before dying under somewhat mysterious circumstances. His election was subsequently pronounced null by Pope John IX because Boniface had been previously defrocked while serving as a Roman priest.
It's about one-three-hundred-thousandth as long as The Apollo 11 Mission
In other words, 2.250 seconds is 0.000003200050 times the length of The Apollo 11 Mission, and the length of The Apollo 11 Mission is 312,495 times that amount.(1969) (total mission length)
The first trip by humans to the surface of the Moon, the Apollo 11 Mission began with the launch of the spacecraft from the Kennedy Space Center in Florida on July 16th, 1969 and concluded with the return of the command module on July 24th, 1969 — a total mission time of 1 weeks, 1 days, 3 hours, 18 minutes, and 35 seconds. The total time spent by astronauts Neil Armstrong and Edwin "Buzz" Aldrin on the Moon's surface was 2 hours, 36 minutes, and 40 seconds.